Endothelial cell binding by human polyclonal anti-DNA antibodies: relationship to disease activity and endothelial functional alterations
نویسندگان
چکیده
منابع مشابه
Anti-endothelial cell antibodies in Behçet's disease.
OBJECTIVE Circulating antibodies that bind to human endothelial cells cultured in vitro have been detected in a variety of diseases, including Behçet's disease. In this disorder the reported prevalence of AECA has varied widely. One likely source of variability is the ELISA assay itself, in which differing conditions and reagents have been used in different reports. METHODS We have re-examine...
متن کاملAntibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity.
OBJECTIVES To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS Thirty patients with BD were prospectively and consecutively studied. The aEC were dete...
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Background: The unique expression of fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL) has been previously reported. Detecting FMOD in CLL patients using specific anti-FMOD mAbs might provide a promising method in detection, monitoring, and prognosis of CLL. Objectives: In this study, we aimed for producing specific antibodies agains...
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Background and objectives: Circulating anti-endothelial cell antibodies (AECAs) are elevated in peripheral arterial disease (PAD) patients. In this context, these autoantibodies have been associated with the endothelial dysfunction and the pro-inflammatory status that surrounds atherosclerosis. On the other hand, white blood cell (WBC) count and inflammatory markers have been consistently assoc...
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As a result of damaging endothelial cells (ECs), Mycobacterium leprae triggers the production of antibodies (Abs). These anti-EC Abs (AECAs) can be divided into two types. The first type nonspecifically reacts with components of the cytosol (CY) and can be detected by enzyme-linked immunosorbent assay (ELISA). The second specifically reacts with the EC membrane (MB) and requires fluorescence-ac...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1995.tb03730.x